phytate in poultry rations containing rice bran (rb) critically reduce poultry performance while increasing n and p excretion. the objective of this study was to determine whether the anti-nutritive problems associated with higher inclusions of rice bran in poultry rations (up to 40%) could be mitigated with mega doses of phytase. twenty days old male broiler chicks (n=180) in 60 floor pens wer...

Phytate in poultry rations containing rice bran (RB) critically reduce poultry performance while increasing N and P excretion. The objective of this study was to determine whether the anti-nutritive problems associated with higher inclusions of rice bran in poultry rations (up to 40%) could be mitigated with mega doses of phytase. Twenty days old male broiler chicks (n=180) in 60 floor pens wer...

The case histories of two patients with penicillin-induced haemolytic anaemia are presented. One had received 20 mega units a day for 18 days, the other had received 20 mega units a day for two days and then 12 mega units a day for 25 days, before the haemolytic anaemia was diagnosed. Both had previously had courses of penicillin. A strongly positive direct antiglobulin reaction which appeared ...

High-dose-methotrexate therapy with eitrovorum factor (leucovorin) rescue has been widely used in the treatment of many solid tumors and lymphomas. This therapy plays an important role in the management of osteosarcoma. The rationale behind using high doses of this drug is to achieve high plasma levels (10 to 10-5 M)for prolonged periods. This probably facilitates the passive entry of methotrex...

BACKGROUND Chronic lymphocytic leukaemia (CLL) is the most common adult leukaemia. Combination immunochemotherapy such as fludarabine, cyclophosphamide and rituximab is the standard first line therapy in fit patients, but there is limited evidence regarding the optimal treatment of patients after relapse. Ofatumumab as monotherapy has been proven to be effective in the treatment of relapsed, re...

Therapeutic benefits of vitamin C is an area of active research and large doses have been suggested by many studies for treatment of various conditions. We are describing a case of oxalate nephropathy leading to end stage kidney disease, which occurred secondary to mega-dose of oral vitamin C. Increasing the awareness between medical personnel as well as patients will clearly decrease the incid...

A case of bacterial endocarditis due to a highly resistant strain of Streptococcus faecalis is described. Although some measure of control of infection was obtained by a combined course of fucidic acid and penicillin the condition relapsed immediately the drugs were discontinued. Finally, the intravenous administration of penicillin in doses of 100 mega units daily for 3 months in conjunction w...

 B-complex vitamins and vitamin C are water-soluble vitamins that are not stored in the body and must be replaced each day.  These vitamins are easily destroyed or washed out during food storage and preparation.  The B-complex group is found in a variety of foods: cereal grains, meat, poultry, eggs, fish, milk, legumes and fresh vegetables.  Citrus fruits are good sources of vitamin C.  Us...

A 32-year-old male developed recurrent ventricular tachycardia after taking mega doses of loperamide and famotidine in order to experience an opiate-like euphoric effect. He was taking up to 200 mg of loperamide and multiple doses of famotidine each day. He developed palpitations and syncope. Electrocardiography demonstrated ventricular tachycardia and QT interval prolongation (corrected QT int...

We recently reported that Metadichol® [1] brings about a three to four-fold increase in Vitamin C levels in patients without the use of Vitamin C supplementation. In this study of 6 patients who experienced a 5-12 fold increase in plasma Vitamin C levels higher than 80-100 u mol/L level which is the highest reported to date by oral supplementation at high doses of Vitamin C. Metadichol improved...